Volume 9/Issue 2, March 2013
Severe combined immunodeficiency in the newborn
Paraskevi Maggina, Andrew R Gennery
Severe combined immunodeficiencies (SCIDs) are a group of rare diseases of T-lymphocyte or thymic failure, which comprise the most severe immunodeficiencies. Generally fatal by one year of age without treatment, they constitute a paediatric emergency and early diagnosis facilitates a better prognosis. This article will review the molecular mechanisms of SCID, clinical signs and symptoms, diagnostic investigations and review treatment modalities and outcomes, and discuss future developments.
Maggina P., Gennery A.R. Severe combined immunodeficiency in the newborn.Infant 2013; 9(2): 52-55.